Communication

A Hydrogen Peroxide-Responsive O2 Nanogenerator for Ultrasound and Magnetic-Resonance Dual Modality Imaging

  1. Fang Yang1,
  2. Sunling Hu1,
  3. Yu Zhang1,
  4. Xiaowei Cai1,
  5. Yan Huang2,
  6. Feng Wang2,
  7. Song Wen3,
  8. Gaojun Teng3,
  9. Ning Gu1,*

Article first published online: 18 JUL 2012

DOI: 10.1002/adma.201202367

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 38, pages 5205–5211, October 2, 2012

Additional Information

How to Cite

Yang, F., Hu, S., Zhang, Y., Cai, X., Huang, Y., Wang, F., Wen, S., Teng, G. and Gu, N. (2012), A Hydrogen Peroxide-Responsive O2 Nanogenerator for Ultrasound and Magnetic-Resonance Dual Modality Imaging. Adv. Mater., 24: 5205–5211. doi: 10.1002/adma.201202367

Author Information

  1. 1

    State Key Laboratory of Bioeletronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China

  2. 2

    Nuclear Medicine Department, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China

  3. 3

    Department of Radiology, Zhong Da Hospital, School of Clinical Medicine, Southeast University, Nanjing, 210009, China

*State Key Laboratory of Bioeletronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.

Publication History

  1. Issue published online: 25 SEP 2012
  2. Article first published online: 18 JUL 2012
  3. Manuscript Received: 12 JUN 2012

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Keywords:

  • Prussian Blue nanoparticles;
  • bubble nanogenerators;
  • hydrogen peroxide;
  • ultrasound imaging;
  • magnetic-resonance imaging
Thumbnail image of graphical abstract

It is found that Prussian Blue nanoparticles (PBNPs) possess a catalase-like activity to catalyse the breakdown of H2O2 into oxygen (O2) molecules under the neutral conditions (pH = 7.4). Based on this finding, we have developed a new strategy in which PBNPs can be excellent ultrasound (US) and magnetic-resonance (MR) dual modality imaging contrast agents for H2O2 diagnostics in vitro and in vivo.

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