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Advanced Materials

A Hydrogen Peroxide-Responsive O2 Nanogenerator for Ultrasound and Magnetic-Resonance Dual Modality Imaging

Authors

  • Fang Yang,

    1. State Key Laboratory of Bioeletronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China
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  • Sunling Hu,

    1. State Key Laboratory of Bioeletronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China
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  • Yu Zhang,

    1. State Key Laboratory of Bioeletronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China
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  • Xiaowei Cai,

    1. State Key Laboratory of Bioeletronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China
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  • Yan Huang,

    1. Nuclear Medicine Department, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China
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  • Feng Wang,

    1. Nuclear Medicine Department, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China
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  • Song Wen,

    1. Department of Radiology, Zhong Da Hospital, School of Clinical Medicine, Southeast University, Nanjing, 210009, China
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  • Gaojun Teng,

    1. Department of Radiology, Zhong Da Hospital, School of Clinical Medicine, Southeast University, Nanjing, 210009, China
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  • Ning Gu

    Corresponding author
    1. State Key Laboratory of Bioeletronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China
    • State Key Laboratory of Bioeletronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
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Abstract

It is found that Prussian Blue nanoparticles (PBNPs) possess a catalase-like activity to catalyse the breakdown of H2O2 into oxygen (O2) molecules under the neutral conditions (pH = 7.4). Based on this finding, we have developed a new strategy in which PBNPs can be excellent ultrasound (US) and magnetic-resonance (MR) dual modality imaging contrast agents for H2O2 diagnostics in vitro and in vivo.

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