It is found that Prussian Blue nanoparticles (PBNPs) possess a catalase-like activity to catalyse the breakdown of H2O2 into oxygen (O2) molecules under the neutral conditions (pH = 7.4). Based on this finding, we have developed a new strategy in which PBNPs can be excellent ultrasound (US) and magnetic-resonance (MR) dual modality imaging contrast agents for H2O2 diagnostics in vitro and in vivo.
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