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Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous In Vivo Dual-Modal Imaging and Photodynamic Therapy

Authors

  • Yong Il Park,

    1. World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2), Institute of Chemical Processes, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, South Korea
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  • Hyung Min Kim,

    1. Laboratory for Advanced Molecular Probing (LAMP), Research Center for Convergence Nanotechnology, Korea Research Institute of Chemical Technology (KRICT), Daejeon 305-600, South Korea
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  • Jeong Hyun Kim,

    1. World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2), Institute of Chemical Processes, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, South Korea
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  • Kyung Chul Moon,

    1. Department of Laboratory Medicine, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan 425-707, South Korea
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  • Byeongjun Yoo,

    1. World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2), Institute of Chemical Processes, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, South Korea
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  • Kang Taek Lee,

    1. Laboratory for Advanced Molecular Probing (LAMP), Research Center for Convergence Nanotechnology, Korea Research Institute of Chemical Technology (KRICT), Daejeon 305-600, South Korea
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  • Nohyun Lee,

    1. World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2), Institute of Chemical Processes, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, South Korea
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  • Yoonseok Choi,

    1. Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744, South Korea
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  • Wooram Park,

    1. Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, South Korea
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  • Daishun Ling,

    1. World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2), Institute of Chemical Processes, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, South Korea
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  • Kun Na,

    1. Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, South Korea
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  • Woo Kyung Moon,

    1. Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744, South Korea
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  • Seung Hong Choi,

    1. Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744, South Korea
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  • Hong Seok Park,

    1. Department of Urology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul 152-703, South Korea
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  • Soo-Young Yoon,

    Corresponding author
    1. Department of Laboratory Medicine, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan 425-707, South Korea
    • Department of Laboratory Medicine, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan 425-707, South Korea
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  • Yung Doug Suh,

    1. Laboratory for Advanced Molecular Probing (LAMP), Research Center for Convergence Nanotechnology, Korea Research Institute of Chemical Technology (KRICT), Daejeon 305-600, South Korea
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  • Sung Ho Lee,

    Corresponding author
    1. Department of Thoracic and Cardiovascular Surgery, Korea University Anam Hospital, College of Medicine, Korea University, Seoul 136-705, South Korea
    • Department of Thoracic and Cardiovascular Surgery, Korea University Anam Hospital, College of Medicine, Korea University, Seoul 136-705, South Korea.
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  • Taeghwan Hyeon

    Corresponding author
    1. World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2), Institute of Chemical Processes, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, South Korea
    • World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2), Institute of Chemical Processes, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, South Korea
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Abstract

Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core–shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.

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