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Bioinspired Controlled Release of CCL22 Recruits Regulatory T Cells In Vivo

Authors

  • Siddharth Jhunjhunwala,

    1. 360B CNBIO, 300 Technology Drive, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA-15219, USA
    2. 450 Technology Drive, Suite 300, McGowan Institute for Regenerative Medicine, University of Pittsburgh Pittsburgh, PA-15219, USA
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  • Giorgio Raimondi,

    1. 200 Lothrop Street, Department of Surgery, University of Pittsburgh, Pittsburgh, PA-15261, USA
    2. 200 Lothrop Street, W1540, Thomas E. Starzl Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA-15261, USA
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  • Andrew J. Glowacki,

    1. 3700 O'Hara Street, #1249, Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA-15261, USA
    2. 450 Technology Drive, Suite 300, McGowan Institute for Regenerative Medicine, University of Pittsburgh Pittsburgh, PA-15219, USA
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  • Sherri J. Hall,

    1. 360B CNBIO, 300 Technology Drive, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA-15219, USA
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  • Dan Maskarinec,

    1. 360B CNBIO, 300 Technology Drive, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA-15219, USA
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  • Stephen H. Thorne,

    1. 200 Lothrop Street, Department of Surgery, University of Pittsburgh, Pittsburgh, PA-15261, USA
    2. 200 Lothrop Street, E1040, Thomas E. Starzl Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA-15261, USA
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  • Angus W. Thomson,

    1. 200 Lothrop Street, Department of Surgery, University of Pittsburgh, Pittsburgh, PA-15261, USA
    2. 200 Lothrop Street, E1040, Thomas E. Starzl Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA-15261, USA
    3. 200 Lothrop Street, W1540, Thomas E. Starzl Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA-15261, USA
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  • Steven R. Little

    Corresponding author
    1. 360B CNBIO, 300 Technology Drive, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA-15219, USA
    2. 3700 O'Hara Street, #1249, Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA-15261, USA
    3. 200 Lothrop Street, E1040, Thomas E. Starzl Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA-15261, USA
    4. 450 Technology Drive, Suite 300, McGowan Institute for Regenerative Medicine, University of Pittsburgh Pittsburgh, PA-15219, USA
    • 360B CNBIO, 300 Technology Drive, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA-15219, USA.
    Search for more papers by this author

Abstract

A rationally designed controlled-release system is developed to recruit suppressive immune cells to specific sites in vivo. Continuous and sustained release of the chemokine CCL22 is achieved by fabricating porous polymeric microspheres. Application of these porous particles in vivo, in mice, leads to local regulatory T cell recruitment as well as a delay in rejection responses against transplanted allogeneic cells.

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