Communication

Measurement of Barrier Tissue Integrity with an Organic Electrochemical Transistor

  1. Leslie H Jimison1,
  2. Scherrine A. Tria1,
  3. Dion Khodagholy1,
  4. Moshe Gurfinkel1,
  5. Erica Lanzarini2,
  6. Adel Hama1,
  7. George G. Malliaras1,
  8. Róisín M. Owens1,*

Article first published online: 5 SEP 2012

DOI: 10.1002/adma.201202612

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 44, pages 5919–5923, November 20, 2012

Additional Information

How to Cite

Jimison, L. H., Tria, S. A., Khodagholy, D., Gurfinkel, M., Lanzarini, E., Hama, A., Malliaras, G. G. and Owens, R. M. (2012), Measurement of Barrier Tissue Integrity with an Organic Electrochemical Transistor. Adv. Mater., 24: 5919–5923. doi: 10.1002/adma.201202612

Author Information

  1. 1

    Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France

  2. 2

    Center for Nano Science and Technology @ Polimi, Instituto Italiano di Technologia, Via Giovanni Pascoli 70/3, Milano 20133, Italy

*Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France.

Publication History

  1. Issue published online: 20 NOV 2012
  2. Article first published online: 5 SEP 2012
  3. Manuscript Revised: 4 AUG 2012
  4. Manuscript Received: 28 JUN 2012

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Keywords:

  • Bioelectronics;
  • barrier tissue;
  • PEDOT;
  • toxicology;
  • organic electrochemical transistors
Thumbnail image of graphical abstract

The integration of an organic electrochemical transistor with human barrier tissue cells provides a novel method for assessing toxicology of compounds in vitro. Minute variations in paracellular ionic flux induced by toxic compounds are measured in real time, with unprecedented temporal resolution and extreme sensitivity.

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