Advanced Materials

Measurement of Barrier Tissue Integrity with an Organic Electrochemical Transistor

Authors

  • Leslie H Jimison,

    1. Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France
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  • Scherrine A. Tria,

    1. Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France
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  • Dion Khodagholy,

    1. Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France
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  • Moshe Gurfinkel,

    1. Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France
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  • Erica Lanzarini,

    1. Center for Nano Science and Technology @ Polimi, Instituto Italiano di Technologia, Via Giovanni Pascoli 70/3, Milano 20133, Italy
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  • Adel Hama,

    1. Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France
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  • George G. Malliaras,

    1. Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France
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  • Róisín M. Owens

    Corresponding author
    1. Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France
    • Department of Bioelectronics, Ecole Nationale Superieure des Mines, CMP-EMSE, MOC, 880 Rue de Mimet, Gardanne 13541, France.
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Abstract

The integration of an organic electrochemical transistor with human barrier tissue cells provides a novel method for assessing toxicology of compounds in vitro. Minute variations in paracellular ionic flux induced by toxic compounds are measured in real time, with unprecedented temporal resolution and extreme sensitivity.

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