Unraveling Stress-Induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism

Authors

  • Wendi Zhang,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
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  • Chi Wang,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
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  • Zhongjun Li,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
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  • Zhenzhen Lu,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
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  • Yiye Li,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
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  • Jun-Jie Yin,

    1. Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA
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  • Yu-Ting Zhou,

    1. Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA
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  • Xingfa Gao,

    1. Institute of High Energy Physics, CAS, Beijing 1000049, China
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  • Ying Fang,

    Corresponding author
    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
    • CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China.

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  • Guangjun Nie,

    Corresponding author
    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
    • CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China.

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  • Yuliang Zhao

    Corresponding author
    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
    2. Institute of High Energy Physics, CAS, Beijing 1000049, China
    • CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China.

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Abstract

original image

Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.

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