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Keywords:

  • nanoparticles;
  • drug delivery;
  • drug cocktail;
  • multicompartment;
  • intracellular release
Thumbnail image of graphical abstract

A nano cocktail, NCPD, fabricated from a pH and redox dual responsive polymer shows a multicompartment structure. The NCPD nanogel is stable in physiological environments while intracellular spontaneous swelling and fast releasing its payload. NCPD displays much stronger synergism than its free drug counterpart, which suggests that NCPD could greatly attenuate the side effects of drug cocktails while boosting synergistic anticancer effects.