Get access
Advanced Materials

Multicompartment Intracellular Self-Expanding Nanogel for Targeted Delivery of Drug Cocktail

Authors

  • Remant Bahadur K. C.,

    1. Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 715 Sumter, Columbia, SC 29208, USA
    Search for more papers by this author
  • Peisheng Xu

    Corresponding author
    1. Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 715 Sumter, Columbia, SC 29208, USA
    2. Nanocenter and Center for Colon Cancer Research, University of South Carolina, 712 Main Street, Columbia, SC 29208, USA
    • Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 715 Sumter, Columbia, SC 29208, USA.
    Search for more papers by this author

Abstract

A nano cocktail, NCPD, fabricated from a pH and redox dual responsive polymer shows a multicompartment structure. The NCPD nanogel is stable in physiological environments while intracellular spontaneous swelling and fast releasing its payload. NCPD displays much stronger synergism than its free drug counterpart, which suggests that NCPD could greatly attenuate the side effects of drug cocktails while boosting synergistic anticancer effects.

original image
Get access to the full text of this article

Ancillary