Communication

One-Pot Synthesis of Spheres-on-Sphere Silica Particles from a Single Precursor for Fast HPLC with Low Back Pressure

  1. Adham Ahmed1,
  2. Harald Ritchie2,
  3. Peter Myers1,
  4. Haifei Zhang1,*

Article first published online: 31 AUG 2012

DOI: 10.1002/adma.201202810

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 45, pages 6042–6048, November 27, 2012

Additional Information

How to Cite

Ahmed, A., Ritchie, H., Myers, P. and Zhang, H. (2012), One-Pot Synthesis of Spheres-on-Sphere Silica Particles from a Single Precursor for Fast HPLC with Low Back Pressure. Adv. Mater., 24: 6042–6048. doi: 10.1002/adma.201202810

Author Information

  1. 1

    Department of Chemistry, University of Liverpool, Oxford Street, Liverpool, L69 7ZD, UK

  2. 2

    Thermo Fisher Scientific, Tudor Road, Manor Park, Runcorn, WA7 1TA, UK

*Department of Chemistry, University of Liverpool, Oxford Street, Liverpool, L69 7ZD, UK.

Publication History

  1. Issue published online: 20 NOV 2012
  2. Article first published online: 31 AUG 2012
  3. Manuscript Revised: 1 AUG 2012
  4. Manuscript Received: 11 JUL 2012

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Keywords:

  • silica spheres;
  • high-performance liquid chromatography (HPLC);
  • core-shell structures;
  • protein separation
Thumbnail image of graphical abstract

Spheres-on-sphere (SOS) silica particles are prepared in a one-pot scalable synthesis from mercaptopropyltrimethoxysilane with hydrophilic polymer and cationic surfactant under alkaline conditions. The SOS particles exhibit solid-core porous-shell properties. The fast separation of small molecules and proteins with low back pressure are demonstrated by high-performance liquid chromatography (HPLC) for the columns packed with SOS-particles.

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