Bacteria-Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery

Authors

  • Meng-Hua Xiong,

    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
    Current affiliation:
    1. These authors contributed equally to this work.
    Search for more papers by this author
  • Ya-Juan Li,

    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China, Fax: (+) 86 551 3600402
    Current affiliation:
    1. These authors contributed equally to this work.
    Search for more papers by this author
  • Yan Bao,

    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China, Fax: (+) 86 551 3600402
    Search for more papers by this author
  • Xian-Zhu Yang,

    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China, Fax: (+) 86 551 3600402
    Search for more papers by this author
  • Bing Hu,

    Corresponding author
    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China, Fax: (+) 86 551 3600402
    • Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China, Fax: (+) 86 551 3600402.
    Search for more papers by this author
  • Jun Wang

    Corresponding author
    1. Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China, Fax: (+) 86 551 3600402
    • Hefei National Laboratory for Physical Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China, Fax: (+) 86 551 3600402.
    Search for more papers by this author

Abstract

original image

Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition.

Ancillary