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Fragmentation of Poly(lactic acid) Nanosheets and Patchwork Treatment for Burn Wounds

Authors

  • Yosuke Okamura,

    Corresponding author
    1. Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, TWIns, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan
    2. Institute of Innovative Science and Technology, Tokai University, 4-1-1 Kitakaname, Hiratsuka, Kanagawa, 259-1292, Japan
    • Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, TWIns, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan.
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  • Koki Kabata,

    1. Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, TWIns, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan
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  • Manabu Kinoshita,

    1. Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan
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  • Hiromi Miyazaki,

    1. Division of Traumatology, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan
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  • Akihiro Saito,

    1. Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, TWIns, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan
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  • Toshinori Fujie,

    1. Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, TWIns, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan
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  • Shinya Ohtsubo,

    1. Project Research Institutes, Comprehensive Research Organization, Waseda University, Shinjuku-ku, Tokyo, 162-0041, Japan
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  • Daizoh Saitoh,

    1. Division of Traumatology, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan
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  • Shinji Takeoka

    Corresponding author
    1. Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, TWIns, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan
    • Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, TWIns, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, 162-8480, Japan.
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Abstract

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Freestanding poly(L-lactic acid) (PLLA) nanosheets are mass-produced by a simple combination of a spin-coating-assisted multi-layering process and a peeling technique. The resulting PLLA nanosheets are fragmented by homogenization and then reconstructed into a “patchwork” sheet on various surfaces without any adhesive reagents. The patchwork is shown to offer excellent protection against burn wound infection with Pseudomonas aeruginosa, and may therefore be an alternative to conventional burn therapy for prevention of infection.

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