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Advanced Materials

Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels

Authors

  • Daniel A. Heller,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Yair Levi,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Jeisa M. Pelet,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Joshua C. Doloff,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
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  • Jasmine Wallas,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
    4. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
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  • George W. Pratt,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
    4. Department of Bioengineering, Boston University, Boston, MA 02215, USA
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  • Shan Jiang,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • Gaurav Sahay,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • Avi Schroeder,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
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  • Josh E. Schroeder,

    1. Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY 10065, USA
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  • Yieu Chyan,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • Christopher Zurenko,

    1. Alnylam Pharmaceuticals, Inc., Cambridge, MA 02142, USA
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  • William Querbes,

    1. Alnylam Pharmaceuticals, Inc., Cambridge, MA 02142, USA
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  • Miguel Manzano,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    3. Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
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  • Daniel S. Kohane,

    1. Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
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  • Robert Langer,

    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Division of Health Science Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • Daniel G. Anderson

    Corresponding author
    1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    3. Department of Anesthesiology, Children's Hospital Boston, Boston, MA 02115, USA
    4. Division of Health Science Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    • David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Abstract

A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.

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