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Keywords:

  • plasmid DNA;
  • templated self-assembly;
  • shape control;
  • solvent polarity;
  • gene delivery
Thumbnail image of graphical abstract

DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.