Communication

Plasmid-Templated Shape Control of Condensed DNA–Block Copolymer Nanoparticles

  1. Xuan Jiang1,2,†,
  2. Wei Qu3,†,
  3. Deng Pan4,
  4. Yong Ren1,
  5. John-Michael Williford4,
  6. Honggang Cui5,
  7. Erik Luijten3,6,*,
  8. Hai-Quan Mao1,2,*

Article first published online: 11 OCT 2012

DOI: 10.1002/adma.201202932

Issue

Advanced Materials

Advanced Materials

Volume 25, Issue 2, pages 227–232, January 11, 2013

Additional Information

How to Cite

Jiang, X., Qu, W., Pan, D., Ren, Y., Williford, J.-M., Cui, H., Luijten, E. and Mao, H.-Q. (2013), Plasmid-Templated Shape Control of Condensed DNA–Block Copolymer Nanoparticles. Adv. Mater., 25: 227–232. doi: 10.1002/adma.201202932

Author Information

  1. 1

    Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA

  2. 2

    Translational Tissue Engineering Center and Whitaker Biomedical Engineering Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA

  3. 3

    Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA

  4. 4

    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA

  5. 5

    Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA

  6. 6

    Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois 60208, USA

  1. †

    These authors contributed equally to this work.

*Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois 60208, USA.

Publication History

  1. Issue published online: 7 JAN 2013
  2. Article first published online: 11 OCT 2012
  3. Manuscript Revised: 3 SEP 2012
  4. Manuscript Received: 23 JUL 2012

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Keywords:

  • plasmid DNA;
  • templated self-assembly;
  • shape control;
  • solvent polarity;
  • gene delivery
Thumbnail image of graphical abstract

DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.

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