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Advanced Materials

Plasmid-Templated Shape Control of Condensed DNA–Block Copolymer Nanoparticles

Authors

  • Xuan Jiang,

    1. Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    2. Translational Tissue Engineering Center and Whitaker Biomedical Engineering Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Wei Qu,

    1. Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Deng Pan,

    1. Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
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  • Yong Ren,

    1. Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
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  • John-Michael Williford,

    1. Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
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  • Honggang Cui,

    1. Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
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  • Erik Luijten,

    Corresponding author
    1. Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA
    2. Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois 60208, USA
    • Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois 60208, USA.
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  • Hai-Quan Mao

    Corresponding author
    1. Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    2. Translational Tissue Engineering Center and Whitaker Biomedical Engineering Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    • Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
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Abstract

DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.

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