Advanced Materials

A Synergistically Enhanced T1T2 Dual-Modal Contrast Agent

Authors

  • Zijian Zhou,

    1. State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China
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  • Dengtong Huang,

    1. State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China
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  • Jianfeng Bao,

    1. Department of Electronic Science and Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, P. R. China
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  • Qiaoli Chen,

    1. State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China
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  • Gang Liu,

    1. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, P. R. China
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  • Zhong Chen,

    1. Department of Electronic Science and Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, P. R. China
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  • Xiaoyuan Chen,

    1. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, P. R. China
    2. Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
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  • Jinhao Gao

    Corresponding author
    1. State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China
    2. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, P. R. China
    • State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China.
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Abstract

Monodisperse Gd2O3-embedded iron oxide (GdIO) nanoparticles can simultaneously enhance the local magnetic field intensities of each other under an external magnetic field and result in synergistic enhancement of T1 and T2 effects. GdIO nanoparticles have the unique property to be both T1 and T2 contrast agents and can potentially lead to higher accuracy in cancer diagnosis, particularly liver tumors.

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