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A Sensitive H2O2 Assay Based on Dumbbell-like PtPd-Fe3O4 Nanoparticles

  1. Xiaolian Sun1,
  2. Shaojun Guo1,
  3. Chun-Shiang Chung2,
  4. Wenlei Zhu1,
  5. Shouheng Sun1,*

Article first published online: 12 OCT 2012

DOI: 10.1002/adma.201203218

Issue

Advanced Materials

Advanced Materials

Volume 25, Issue 1, pages 132–136, January 4, 2013

Additional Information

How to Cite

Sun, X., Guo, S., Chung, C.-S., Zhu, W. and Sun, S. (2013), A Sensitive H2O2 Assay Based on Dumbbell-like PtPd-Fe3O4 Nanoparticles. Adv. Mater., 25: 132–136. doi: 10.1002/adma.201203218

Author Information

  1. 1

    Department of Chemistry, Brown University, Providence, RI 02912, USA

  2. 2

    Department of Surgery, Brown University/Rhode Island Hospital, Providence, RI 02903, USA

*Department of Chemistry, Brown University, Providence, RI 02912, USA.

Publication History

  1. Issue published online: 2 JAN 2013
  2. Article first published online: 12 OCT 2012
  3. Manuscript Revised: 19 SEP 2012
  4. Manuscript Received: 5 AUG 2012

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Keywords:

  • PtPd alloy nanoparticles;
  • Iron oxide nanoparticles;
  • dumbbell nanoparticles;
  • synergistic effect;
  • H2O2 assay
Thumbnail image of graphical abstract

Dumbbell-like Pt48Pd52-Fe3O4 nanoparticles are synthesized and functionalized with oleylamine-polyethyleneglycol to serve as an efficient catalyst for H2O2 reduction and tetramethylbenzidine (TMB) oxidation in biological solutions. The Pt48Pd52-Fe3O4/TMB kit is even more active than the natural enzyme for H2O2 detection with a detection limit reaching 2 μM, and is successfully used to quantitatively monitor the extracellular H2O2 generated by neutrophils.

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