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Simple Precision Creation of Digitally Specified, Spatially Heterogeneous, Engineered Tissue Architectures

Authors

  • Umut Atakan Gurkan,

    1. Harvard Medical School, Division of Biomedical Engineering at Brigham and Women's Hospital, Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Harvard-MIT Health Sciences & Technology, 65 Landsdowne St. PRB 252, Cambridge, MA 02139, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Yantao Fan,

    1. Harvard Medical School, Division of Biomedical Engineering at Brigham and Women's Hospital, Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Harvard-MIT Health Sciences & Technology, 65 Landsdowne St. PRB 252, Cambridge, MA 02139, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Feng Xu,

    1. Harvard Medical School, Division of Biomedical Engineering at Brigham and Women's Hospital, Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Harvard-MIT Health Sciences & Technology, 65 Landsdowne St. PRB 252, Cambridge, MA 02139, USA
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  • Burcu Erkmen,

    1. Harvard Medical School, Division of Biomedical Engineering at Brigham and Women's Hospital, Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Harvard-MIT Health Sciences & Technology, 65 Landsdowne St. PRB 252, Cambridge, MA 02139, USA
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  • Emel Sokullu Urkac,

    1. Harvard Medical School, Division of Biomedical Engineering at Brigham and Women's Hospital, Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Harvard-MIT Health Sciences & Technology, 65 Landsdowne St. PRB 252, Cambridge, MA 02139, USA
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  • Gunes Parlakgul,

    1. Harvard Medical School, Division of Biomedical Engineering at Brigham and Women's Hospital, Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Harvard-MIT Health Sciences & Technology, 65 Landsdowne St. PRB 252, Cambridge, MA 02139, USA
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  • Jacob Bernstein,

    1. Media Lab and McGovern Institute, Departments of Brain and Cognitive Sciences and Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
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  • Wangli Xing,

    Corresponding author
    1. Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, PR China, National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing, 102206, P. R. China
    • Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing 100084, PR China, National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing, 102206, P. R. China
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  • Edward S. Boyden,

    Corresponding author
    1. Media Lab and McGovern Institute, Departments of Brain and Cognitive Sciences and Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    • Media Lab and McGovern Institute, Departments of Brain and Cognitive Sciences and Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
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  • Utkan Demirci

    Corresponding author
    1. Harvard Medical School, Brigham and Women's Hospital, Harvard-MIT Health Sciences & Technology, 65 Landsdowne St. PRB 252, Cambridge, MA 02139, USA
    • Harvard Medical School, Brigham and Women's Hospital, Harvard-MIT Health Sciences & Technology, 65 Landsdowne St. PRB 252, Cambridge, MA 02139, USA.
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Abstract

Complex architectures of integrated circuits are achieved through multiple layer photolithography, which has empowered the semiconductor industry. We adapt this philosophy for tissue engineering with a versatile, scalable, and generalizable microfabrication approach to create engineered tissue architectures composed of digitally specifiable building blocks, each with tuned structural, cellular, and compositional features.

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