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Advanced Materials

Functionalizing Calcium Phosphate Biomaterials with Antibacterial Silver Particles

Authors

  • Jae Sung Lee,

    1. Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706, USA
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  • William L. Murphy

    Corresponding author
    1. Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706, USA
    2. Department of Orthopedics and Rehabilitation, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    3. Collaborative Research Center, AO Foundation, Davos, Switzerland
    • Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706, USA.
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Abstract

Antimicrobial silver particles are created on calcium phosphate (CaP) biomaterials by sequentially incubating in citric acid and silver nitrate solutions. The subsequent silver release kinetics and released dosage are controlled by simply changing the solution conditions during growth of silver particles. Released silver efficiently suppresses the growth of gram-positive Staphylococcus aureus and gram-negative Escherichia coli without significant cytotoxicity to eukaryotic cells.

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