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Bilayered Raman-Intense Gold Nanostructures with Hidden Tags (BRIGHTs) for High-Resolution Bioimaging

Authors

  • Naveen Gandra,

    1. Washington University in St. Louis, Department of Mechanical Engineering and Materials Science, 318 Jolley Hall, 1 Brookings Dr., St. Louis, MO 63130, USA, Telephone: 314-935-5407, Fax: 314-935-4014
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  • Srikanth Singamaneni

    Corresponding author
    1. Washington University in St. Louis, Department of Mechanical Engineering and Materials Science, 318 Jolley Hall, 1 Brookings Dr., St. Louis, MO 63130, USA, Telephone: 314-935-5407, Fax: 314-935-4014
    • Washington University in St. Louis, Department of Mechanical Engineering and Materials Science, 318 Jolley Hall, 1 Brookings Dr., St. Louis, MO 63130, USA, Telephone: 314-935-5407, Fax: 314-935-4014.
    Search for more papers by this author

Abstract

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Conventional SERS probes suffer from limited brightness and poor reproducibility and stability making them unsuitable for routine in vivo applications. A novel class of layered SERS probes is demonstrated in which individual nanostructures host electromagnetic hotspots, thus increasing brightness by more than two orders magnitide compared to conventional individual nanostructures.

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