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Communication

Decoupling Cell and Matrix Mechanics in Engineered Microtissues Using Magnetically Actuated Microcantilevers

  1. Ruogang Zhao1,
  2. Thomas Boudou2,
  3. Wei-Gang Wang1,
  4. Christopher S. Chen2,*,
  5. Daniel H. Reich1,*

Article first published online: 28 JAN 2013

DOI: 10.1002/adma.201203585

Issue

Advanced Materials

Advanced Materials

Volume 25, Issue 12, pages 1699–1705, March 25, 2013

Additional Information

How to Cite

Zhao, R., Boudou, T., Wang, W.-G., Chen, C. S. and Reich, D. H. (2013), Decoupling Cell and Matrix Mechanics in Engineered Microtissues Using Magnetically Actuated Microcantilevers. Adv. Mater., 25: 1699–1705. doi: 10.1002/adma.201203585

Author Information

  1. 1

    Department of Physics and Astronomy, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, USA 21218

  2. 2

    Department of Bioengineering, University of Pennsylvania, 510 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA, USA 19104

*Department of Bioengineering, University of Pennsylvania, 510 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA, USA 19104.

Publication History

  1. Issue published online: 18 MAR 2013
  2. Article first published online: 28 JAN 2013
  3. Manuscript Revised: 5 NOV 2012
  4. Manuscript Received: 28 AUG 2012

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Keywords:

  • engineered microtissue;
  • magnetic actuation;
  • fibroblast populated collagen matrix;
  • tissue stiffness;
  • cell contractility
Thumbnail image of graphical abstract

A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loading conditions.

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