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A Highly Tunable Biocompatible and Multifunctional Biodegradable Elastomer

Authors

  • Maria José Nunes Pereira,

    1. Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Harvard-MIT Division of Health Sciences and Technology, 65 Landsdowne St., Cambridge, MA 02139, USA
    2. Biocant- Biotechnology Innovation Center, CNC-Center of Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
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  • Ben Ouyang,

    1. Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Harvard-MIT Division of Health Sciences and Technology, 65 Landsdowne St., Cambridge, MA 02139, USA
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  • Cathryn A. Sundback,

    1. Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School 55 Fruit St., Boston, MA 02114, USA
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  • Nora Lang,

    1. Departments of Cardiac Surgery, Children's Hospital Boston, Harvard Medical School 300 Longwood Av., Boston, MA 02115, USA
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  • Ingeborg Friehs,

    1. Departments of Cardiac Surgery, Children's Hospital Boston, Harvard Medical School 300 Longwood Av., Boston, MA 02115, USA
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  • Shwetha Mureli,

    1. Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Harvard-MIT Division of Health Sciences and Technology, 65 Landsdowne St., Cambridge, MA 02139, USA
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  • Irina Pomerantseva,

    1. Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School 55 Fruit St., Boston, MA 02114, USA
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  • Jacob McFadden,

    1. Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School 55 Fruit St., Boston, MA 02114, USA
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  • Mark C. Mochel,

    1. Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
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  • Olive Mwizerwa,

    1. Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School 55 Fruit St., Boston, MA 02114, USA
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  • Pedro del Nido,

    1. Departments of Cardiac Surgery, Children's Hospital Boston, Harvard Medical School 300 Longwood Av., Boston, MA 02115, USA
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  • Debanjan Sarkar,

    1. Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Harvard-MIT Division of Health Sciences and Technology, 65 Landsdowne St., Cambridge, MA 02139, USA
    2. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA
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  • Peter T. Masiakos,

    1. Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School 55 Fruit St., Boston, MA 02114, USA
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  • Robert Langer,

    1. Department of Chemical Engineering and the David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology 500 Main Street, Cambridge, MA 02139, USA
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  • Lino S. Ferreira,

    Corresponding author
    1. Biocant- Biotechnology Innovation Center, CNC-Center of Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
    • Biocant- Biotechnology Innovation Center, CNC-Center of Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.
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  • Jeffrey M. Karp

    Corresponding author
    1. Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Harvard-MIT Division of Health Sciences and Technology, 65 Landsdowne St., Cambridge, MA 02139, USA
    • Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Harvard Stem Cell Institute, Harvard-MIT Division of Health Sciences and Technology, 65 Landsdowne St., Cambridge, MA 02139, USA
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Abstract

Biodegradable elastomers synthesized under mild conditions with highly tunable mechanical properties are described. These elastomeric biomaterials are biocompatible, exhibit minimal deformation following cyclical tensile loading, and permit tight control over the release kinetics of encapsulated bioactive molecules.

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