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Advanced Materials

Hydrophobic Interaction-Mediated Capture and Release of Cancer Cells on Thermoresponsive Nanostructured Surfaces

Authors

  • Hongliang Liu,

    1. Beijing National Laboratory for Molecular, Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
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  • Xueli Liu,

    1. Beijing National Laboratory for Molecular, Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, P. R. China
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  • Jingxin Meng,

    1. Beijing National Laboratory for Molecular, Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
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  • Pengchao Zhang,

    1. Beijing National Laboratory for Molecular, Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, P. R. China
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  • Gao Yang,

    1. Graduate School of the Chinese Academy of Sciences, Beijing 100049, P. R. China
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  • Bin Su,

    1. Beijing National Laboratory for Molecular, Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
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  • Kang Sun,

    1. Beijing National Laboratory for Molecular, Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
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  • Li Chen,

    1. Beijing National Laboratory for Molecular, Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
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  • Dong Han,

    1. National Centre for NanoScience and Technology, Beijing, 100190, P. R. China
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  • Shutao Wang,

    Corresponding author
    1. Beijing National Laboratory for Molecular, Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
    • Beijing National Laboratory for Molecular, Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
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  • Lei Jiang

    1. Beijing National Laboratory for Molecular, Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
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Abstract

Capture and release of cancer cells: a thermoresponsive nanostructured surface is designed to reversibly capture and release cancer cells, wherein hydrophobic interaction helps the realization of target capture/release of cancer cells. The unique nature of the designed platform is based on the synergistic effect of hydrophobic interactions between the smart surface and the hydrophobic anchor (i.e., biotin-BSA), and topographic interactions between the nanostructured substrates and cancer cells.

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