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Keywords:

  • vesicles;
  • nanoparticles;
  • magnetic;
  • perfluorocarbons;
  • magnetic resonance imaging;
  • ultrasound;
  • HIFU therapy
Thumbnail image of graphical abstract

Multifunctional organic/inorganic hybrid nanovesicles, fabricated by a facile self-assembly/sol-gel approach, display a unique morphology (figure) and satisfactory stability under physiological conditions. By co-encapsulation of superparamagnetic magnetite nanoparticles and a liquid perfluorocarbon, the nanovesicles can be used not only as a dual-modality ultrasound/magnetic resonance contrast agent for accurate cancer diagnosis and monitoring, but also as a therapeutic enhancement agent for effective high-intensity focused ultrasound (HIFU) ablation.