Facile Synthesis of Magnetite/Perfluorocarbon Co-Loaded Organic/Inorganic Hybrid Vesicles for Dual-Modality Ultrasound/Magnetic Resonance Imaging and Imaging-Guided High-Intensity Focused Ultrasound Ablation

Authors

  • Dechao Niu,

    1. Laboratory of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China
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  • Xia Wang,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China
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  • Yongsheng Li,

    Corresponding author
    1. Laboratory of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China
    • Laboratory of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
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  • Yuanyi Zheng,

    1. Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P. R. China
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  • Faqi Li,

    1. Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, P. R. China
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  • Hangrong Chen,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China
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  • Jinlou Gu,

    1. Laboratory of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China
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  • Wenru Zhao,

    1. Laboratory of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China
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  • Jianlin Shi

    Corresponding author
    1. Laboratory of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China
    2. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China
    • Laboratory of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
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Abstract

original image

Multifunctional organic/inorganic hybrid nanovesicles, fabricated by a facile self-assembly/sol-gel approach, display a unique morphology (figure) and satisfactory stability under physiological conditions. By co-encapsulation of superparamagnetic magnetite nanoparticles and a liquid perfluorocarbon, the nanovesicles can be used not only as a dual-modality ultrasound/magnetic resonance contrast agent for accurate cancer diagnosis and monitoring, but also as a therapeutic enhancement agent for effective high-intensity focused ultrasound (HIFU) ablation.

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