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Incorporating Graphene Oxide and Gold Nanoclusters: A Synergistic Catalyst with Surprisingly High Peroxidase-Like Activity Over a Broad pH Range and its Application for Cancer Cell Detection

Authors

  • Yu Tao,

    1. State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun, Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Youhui Lin,

    1. State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun, Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Zhenzhen Huang,

    1. State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun, Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Jinsong Ren,

    Corresponding author
    1. State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun, Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
    • State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun, Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.===

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  • Xiaogang Qu

    Corresponding author
    1. State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun, Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
    • State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun, Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.===

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Abstract

A synergistic graphene oxide–gold nanocluster (GO-AuNC) hybrid has been constructed as an enzyme mimic that is able to show high catalytic activity over a broad pH range, especially at neutral pH. Importantly, the target-functionalized hybrid has been applied as a robust nanoprobe for selective, quantitative, and fast colorimetric detection of cancer cells.

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