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Advanced Materials

Highly Discriminating Photorelease of Anticancer Drugs Based on Hypoxia Activatable Phototrigger Conjugated Chitosan Nanoparticles

Authors

  • Qiuning Lin,

    1. Shanghai Key Laboratory of Functional, Materials Chemistry, Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China
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  • Chunyan Bao,

    1. Shanghai Key Laboratory of Functional, Materials Chemistry, Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China
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  • Yunlong Yang,

    1. Shanghai Key Laboratory of Functional, Materials Chemistry, Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China
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  • Qiannan Liang,

    1. Shanghai Key Laboratory of Functional, Materials Chemistry, Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China
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  • Dasheng Zhang,

    1. Shanghai Key Laboratory of Functional, Materials Chemistry, Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China
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  • Shuiyu Cheng,

    1. Shanghai Key Laboratory of Functional, Materials Chemistry, Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China
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  • Linyong Zhu

    Corresponding author
    1. Shanghai Key Laboratory of Functional, Materials Chemistry, Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China
    • Shanghai Key Laboratory of Functional, Materials Chemistry, Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, 200237, China.
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Abstract

An ultimately selective photorelease system of chitosan-nanoparticles is constructed. Only under unique aspects of tumor-hypoxia physiological conditions, the preliminary locked phototrigger is unlocked by biological reduction to enable the release of the caged drug either by visible light or two-photon near-IR (NIR) excitation. This approach provides a highly discriminating photorelease of anticancer drug to hypoxic tumor cells, but not to healthy normal cells.

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