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Advanced Materials

Silica-Based Branched Hollow Microfibers as a Biomimetic Extracellular Matrix for Promoting Tumor Cell Growth In Vitro and In Vivo

Authors

  • Penghe Qiu,

    1. Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, 73019, USA
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  • Xuewei Qu,

    1. Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, 73019, USA
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  • Daniel J. Brackett,

    1. Health Science Center, University of Oklahoma and Veterans Research and Education Foundation, Oklahoma City, OK 73104, USA
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  • Megan R. Lerner,

    1. Health Science Center, University of Oklahoma and Veterans Research and Education Foundation, Oklahoma City, OK 73104, USA
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  • Dong Li,

    1. Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, 73019, USA
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  • Chuanbin Mao

    Corresponding author
    1. Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, 73019, USA
    • Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, 73019, USA.
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Abstract

A novel scaffold composed of loosely branched hollow silica microfibers that has been proven to be highly biocompatible is proposed for the 3D culture of cancer cells. The MCF-7 cancer cells can grow and proliferate freely inside the scaffold in the form of multicellular spheroids. MCF-7 cancer cells cultured on the current 3D silica scaffold retained significantly more oncological characters than those cultured on the conventional 2D substrate and can serve as in vitro tumor model for studying cancer treatment.

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