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Keywords:

  • cell adhesion;
  • cell patterning;
  • click chemistry;
  • materials science;
  • responsive surfaces
Thumbnail image of graphical abstract

There's an APP for that: cell-repellent APP (azido-[polylysine-g-PEG]) is used to create substrates for spatially controlled dynamic cell adhesion. The simple addition of a functional peptide to the culture medium rapidly triggers cell adhesion. This highly accessible yet powerful technique allows diverse applications, demonstrated through tissue motility assays, patterned coculturing and triggered cell shape change.