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Conjugated Polymer-Coated Bacteria for Multimodal Intracellular and Extracellular Anticancer Activity

Authors

  • Chunlei Zhu,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
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  • Qiong Yang,

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
    • Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
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  • Fengting Lv,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
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  • Libing Liu,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
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  • Shu Wang

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
    • Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
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Abstract

Multifunctional cationic conjugated polyelectrolyte (CP)-coated bacteria are fabricated for drug loading, delivery and release with multimodal anticancer activity. Facilitated by the collaborative release effect caused by CP and an antibiotic polymyxin B, the loaded toxins leak out from the vectors in considerable amounts and lead to tumor cell death. In addition, the CP coated bacterial vectors can sentisize ROS, which favors light-mediated tumor cell killing.

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