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Advanced Materials

Ultrathin PEGylated W18O49 Nanowires as a New 980 nm-Laser-Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo

Authors

  • Zhigang Chen,

    Corresponding author
    1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. of China
    2. Laboratory of Advanced Materials, Department of Chemistry, Fudan University, Shanghai 200433, P. R. of China
    • State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. of China.
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  • Qian Wang,

    1. Department of Orthopedics, Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200080, P. R. of China
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  • Huanli Wang,

    1. College of Environmental Science and Engineering, Donghua University, Shanghai 201620, P. R. of China
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  • Lisha Zhang,

    1. College of Environmental Science and Engineering, Donghua University, Shanghai 201620, P. R. of China
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  • Guosheng Song,

    1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. of China
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  • Linlin Song,

    1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. of China
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  • Junqing Hu,

    Corresponding author
    1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. of China
    • State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. of China.
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  • Hongzhi Wang,

    1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. of China
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  • Jianshe Liu,

    1. College of Environmental Science and Engineering, Donghua University, Shanghai 201620, P. R. of China
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  • Meifang Zhu,

    Corresponding author
    1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. of China
    • State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. of China.
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  • Dongyuan Zhao

    1. Laboratory of Advanced Materials, Department of Chemistry, Fudan University, Shanghai 200433, P. R. of China
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  • Dedicated to Professor Chun-Hui Huang on the occasion of her 80th birthday

Abstract

A new photothermal coupling agent for photothermal ablation (PTA) therapy of tumors is developed based on ultrathin PEGylated W18O49 nanowires. After being injected with the nanowire solution, the in vivo tumors exhibit a rapid temperature rise to 50.0 ± 0.5 °C upon irradiation with NIR laser light at a safe, low intensity (0.72 W cm−2) for 2 min (left-hand mouse in the figure),), resulting in the efficient PTA of cancer cells in vivo in 10 min.

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