Advanced Materials

Large-Scale, Ultrapliable, and Free-Standing Nanomembranes

Authors

  • Edward Kang,

    1. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, 136-703, Republic of Korea
    2. Department of Biomicrosystem Technology, Korea University, Seoul, 136-713, Republic of Korea
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Jihee Ryoo,

    1. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, 136-703, Republic of Korea
    2. Cosmetic R&D Center, Coway Co, Seoul, 153-792, Republic of Korea
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Gi Seok Jeong,

    1. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, 136-703, Republic of Korea
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  • Yoon Young Choi,

    1. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, 136-703, Republic of Korea
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  • Seung Min Jeong,

    1. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, 136-703, Republic of Korea
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  • Jongil Ju,

    1. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, 136-703, Republic of Korea
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  • Seok Chung,

    1. School of Mechanical Engineering, Korea University, Seoul, 136-713, Republic of Korea
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  • Shuichi Takayama,

    1. Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, 48109, USA
    2. Division of Nano-Bio and Chemical Engineering WCU Project, UNIST, Ulsan, 689-798, Republic of Korea
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  • Sang-Hoon Lee

    Corresponding author
    1. Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, 136-703, Republic of Korea
    2. KU-KIST Graduate School of Converging of Sciences & Technologies, Korea University, Seoul, 136-713, Republic of Korea
    • Department of Biomedical Engineering, College of Health Science, Korea University, Seoul, 136-703, Republic of Korea.

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Abstract

The creation and characterization of large-area ultrathin highly pliable free-standing PDMS membranes and their application to the study of cellular epithelia is described. The ultra-thin membranes permitted the straight forward calculation of cell monolayer moduli, derived from measured stress–strain curves. These measurements allowed the unprecedented detection of cellular-level injury in the epithelia caused by the rupture of cell–cell tight junctions in response to stretching.

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