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Communication

Dopamine-Melanin Colloidal Nanospheres: An Efficient Near-Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy

  1. Yanlan Liu1,2,
  2. Kelong Ai1,
  3. Jianhua Liu3,
  4. Mo Deng4,
  5. Yangyang He5,
  6. Lehui Lu1,*

Article first published online: 21 DEC 2012

DOI: 10.1002/adma.201204683

Issue

Advanced Materials

Advanced Materials

Volume 25, Issue 9, pages 1353–1359, March 6, 2013

Additional Information

How to Cite

Liu, Y., Ai, K., Liu, J., Deng, M., He, Y. and Lu, L. (2013), Dopamine-Melanin Colloidal Nanospheres: An Efficient Near-Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy. Adv. Mater., 25: 1353–1359. doi: 10.1002/adma.201204683

Author Information

  1. 1

    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China

  2. 2

    Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

  3. 3

    Department of Radiology, the Second Hospital of Jilin University, Changchun 130022, P.R. China

  4. 4

    Department of Clinical Laboratory, the Second Hospital of Jilin University, Changchun 130022, P.R. China

  5. 5

    Department of Pathology, the Second Hospital of Jilin University, Changchun 130022, P.R. China

*State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China.

Publication History

  1. Issue published online: 4 MAR 2013
  2. Article first published online: 21 DEC 2012
  3. Manuscript Received: 13 NOV 2012

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Keywords:

  • dopamine-melanin;
  • polymers;
  • nanomaterials;
  • biocompatibility;
  • photothermal therapy
Thumbnail image of graphical abstract

A new generation of photothermal therapeutic agents based on biopolymer dopamine-melanin colloidal nanospheres is described. Benefitting from their naturally wide distribution in humans, dopamine-melanin colloidal nanospheres exhibit robust biocompatibility and biodegradability, and provide up to 40% photothermal conversion efficiency. After administration, they can efficiently damage tumors at low power density and short irradiation time without damaging healthy tissues.

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