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Dopamine-Melanin Colloidal Nanospheres: An Efficient Near-Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy

Authors

  • Yanlan Liu,

    1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
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  • Kelong Ai,

    1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China
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  • Jianhua Liu,

    1. Department of Radiology, the Second Hospital of Jilin University, Changchun 130022, P.R. China
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  • Mo Deng,

    1. Department of Clinical Laboratory, the Second Hospital of Jilin University, Changchun 130022, P.R. China
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  • Yangyang He,

    1. Department of Pathology, the Second Hospital of Jilin University, Changchun 130022, P.R. China
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  • Lehui Lu

    Corresponding author
    1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China
    • State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China.
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Abstract

A new generation of photothermal therapeutic agents based on biopolymer dopamine-melanin colloidal nanospheres is described. Benefitting from their naturally wide distribution in humans, dopamine-melanin colloidal nanospheres exhibit robust biocompatibility and biodegradability, and provide up to 40% photothermal conversion efficiency. After administration, they can efficiently damage tumors at low power density and short irradiation time without damaging healthy tissues.

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