• Open Access

Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays

Authors

  • Andrew L. Hook,

    1. Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG72RD, UK
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  • Chien-Yi Chang,

    1. School of Molecular Medical Sciences, University of Nottingham, Nottingham, NG72RD, UK
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  • Jing Yang,

    1. Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG72RD, UK
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  • Steve Atkinson,

    1. School of Molecular Medical Sciences, University of Nottingham, Nottingham, NG72RD, UK
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  • Robert Langer,

    1. Department of Chemical Engineering, Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA
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  • Daniel G. Anderson,

    1. Department of Chemical Engineering, Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA
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  • Martyn C. Davies,

    1. Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG72RD, UK
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  • Paul Williams,

    1. School of Molecular Medical Sciences, University of Nottingham, Nottingham, NG72RD, UK
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  • Morgan R. Alexander

    Corresponding author
    1. Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG72RD, UK
    • Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG72RD, UK.===

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Abstract

original image

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacterial material. The coverage of three bacterial species, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli is assessed.

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