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Advanced Materials

Construction of Robust Enzyme Nanocapsules for Effective Organophosphate Decontamination, Detoxification, and Protection

Authors

  • Wei Wei,

    1. College of Material Science and Engineering, Donghua University, Shanghai 201620, P. R. China
    2. Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Juanjuan Du,

    1. Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Jie Li,

    1. Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA
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  • Ming Yan,

    1. Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA
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  • Qi Zhu,

    1. Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA
    2. School of Chemistry and Chemical Technology, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 200030, P. R. China
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  • Xin Jin,

    1. Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA
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  • Xinyuan Zhu,

    1. School of Chemistry and Chemical Technology, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 200030, P. R. China
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  • Zuming Hu,

    Corresponding author
    1. College of Material Science and Engineering, Donghua University, Shanghai 201620, P. R. China
    • Zuming Hu, College of Material Science and Engineering, Donghua University, Shanghai 201620, P. R. China

      Yi Tang, Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA.

      Yunfeng Lu, Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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  • Yi Tang,

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA
    • Zuming Hu, College of Material Science and Engineering, Donghua University, Shanghai 201620, P. R. China

      Yi Tang, Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA.

      Yunfeng Lu, Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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  • Yunfeng Lu

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA
    • Zuming Hu, College of Material Science and Engineering, Donghua University, Shanghai 201620, P. R. China

      Yi Tang, Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA.

      Yunfeng Lu, Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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Abstract

Nanocapsules of organophosphorous hydrolase with enhanced enzyme activity and stability are prepared via in situ polymerization, providing a novel class of nanoparticles for the decontamination and detoxification of organophosphates such as chemical warfare agents and pesticides. Using the nanocapsules as building blocks, bioactive nanocomposites are also fabricated, enabling their use for organophosphate protection.

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