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Phototherapy: Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease (Adv. Mater. 13/2012)

  1. Meng Li,
  2. Xinjian Yang,
  3. Jinsong Ren,
  4. Konggang Qu,
  5. Xiaogang Qu*

Article first published online: 27 MAR 2012

DOI: 10.1002/adma.201290072

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 13, page 1621, April 3, 2012

Additional Information

How to Cite

Li, M., Yang, X., Ren, J., Qu, K. and Qu, X. (2012), Phototherapy: Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease (Adv. Mater. 13/2012). Adv. Mater., 24: 1621. doi: 10.1002/adma.201290072

Author Information

  1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China, Fax: 86-431-85262656

*Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China, Fax: 86-431-85262656.

Publication History

  1. Issue published online: 27 MAR 2012
  2. Article first published online: 27 MAR 2012

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Keywords:

  • Alzheimer's disease;
  • amyloid;
  • graphene;
  • nanomaterials;
  • phototherapy
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Inhibition of Aβ aggregation has shown promising against Alzheimer's disease in clinical trials. X. Qu and co-workers report a novel strategy on page 1722 which can dissociate amyloid aggregation using local heat generated by a clinically used amyloid-staining, dye-modified graphene oxide (GO) under NIR laser irradiation. With its high NIR absorbance, good biocompatibility, and its ability to cross the blood-brain barrier, the newly synthesized GO can efficiently dissociate Aβ fibrils, protect cells against Aβ-related toxicity, and be monitored in real time.

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