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Phototherapy: Using Graphene Oxide High Near-Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease (Adv. Mater. 13/2012)

Authors

  • Meng Li,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China, Fax: 86-431-85262656
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  • Xinjian Yang,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China, Fax: 86-431-85262656
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  • Jinsong Ren,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China, Fax: 86-431-85262656
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  • Konggang Qu,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China, Fax: 86-431-85262656
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  • Xiaogang Qu

    Corresponding author
    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China, Fax: 86-431-85262656
    • Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P.R. China, Fax: 86-431-85262656.
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Abstract

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Inhibition of Aβ aggregation has shown promising against Alzheimer's disease in clinical trials. X. Qu and co-workers report a novel strategy on page 1722 which can dissociate amyloid aggregation using local heat generated by a clinically used amyloid-staining, dye-modified graphene oxide (GO) under NIR laser irradiation. With its high NIR absorbance, good biocompatibility, and its ability to cross the blood-brain barrier, the newly synthesized GO can efficiently dissociate Aβ fibrils, protect cells against Aβ-related toxicity, and be monitored in real time.

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