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Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles (Adv. Mater. 14/2012)

  1. Kai Yang1,
  2. Lilei Hu1,
  3. Xingxing Ma2,
  4. Shuoqi Ye3,
  5. Liang Cheng1,
  6. Xiaoze Shi1,
  7. Changhui Li3,
  8. Yonggang Li2,
  9. Zhuang Liu1,*

Article first published online: 4 APR 2012

DOI: 10.1002/adma.201290077

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 14, page 1867, April 10, 2012

Additional Information

How to Cite

Yang, K., Hu, L., Ma, X., Ye, S., Cheng, L., Shi, X., Li, C., Li, Y. and Liu, Z. (2012), Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles (Adv. Mater. 14/2012). Adv. Mater., 24: 1867. doi: 10.1002/adma.201290077

Author Information

  1. 1

    Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China

  2. 2

    Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China

  3. 3

    Department of biomedical engineering, college of engineering, Peking University, Beijing, 100871, China

*Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China.

Publication History

  1. Issue published online: 4 APR 2012
  2. Article first published online: 4 APR 2012

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Keywords:

  • graphene oxide nanocomposites;
  • magnetic resonance imaging;
  • photoacoustic imaging;
  • photothermal therapy;
  • multimodal imaging
Thumbnail image of graphical abstract

A nanoscale reduced graphene oxide–iron oxide nanoparticle (RGO–IONP) complex is nonco-valently functionalized with polyethylene glycol (PEG) by Z. Liu and co-workers on page 1868, obtaining a RGO–IONP–PEG nanocomposite which displays excellent physiological stability, strong NIR optical absorbance, and superpara-magnetic properties. This theranostic nanoprobe allows multimodal tumor imaging - in vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for the effective photothermal ablation of tumors in mice.

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