Advanced Materials

Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles (Adv. Mater. 14/2012)

Authors

  • Kai Yang,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
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  • Lilei Hu,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
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  • Xingxing Ma,

    1. Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
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  • Shuoqi Ye,

    1. Department of biomedical engineering, college of engineering, Peking University, Beijing, 100871, China
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  • Liang Cheng,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
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  • Xiaoze Shi,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
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  • Changhui Li,

    1. Department of biomedical engineering, college of engineering, Peking University, Beijing, 100871, China
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  • Yonggang Li,

    1. Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
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  • Zhuang Liu

    Corresponding author
    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
    • Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China.
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Abstract

A nanoscale reduced graphene oxide–iron oxide nanoparticle (RGO–IONP) complex is nonco-valently functionalized with polyethylene glycol (PEG) by Z. Liu and co-workers on page 1868, obtaining a RGO–IONP–PEG nanocomposite which displays excellent physiological stability, strong NIR optical absorbance, and superpara-magnetic properties. This theranostic nanoprobe allows multimodal tumor imaging - in vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for the effective photothermal ablation of tumors in mice.

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