Get access
Advanced Materials

Patterning: Three-Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization (Adv. Mater. 17/2012)

Authors

  • James C. Culver,

    1. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA
    Current affiliation:
    1. These authors contributed equally to this work.
    Search for more papers by this author
  • Joseph C. Hoffmann,

    1. Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA
    Current affiliation:
    1. These authors contributed equally to this work.
    Search for more papers by this author
  • Ross A. Poché,

    1. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA
    Search for more papers by this author
  • John H. Slater,

    1. Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA
    Search for more papers by this author
  • Jennifer L. West,

    Corresponding author
    1. Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA
    • Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA
    Search for more papers by this author
  • Mary E. Dickinson

    Corresponding author
    1. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA
    • Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
    Search for more papers by this author

Abstract

On page 2344, J. L. West, M. E. Dickinson, and co-workers demonstrate an image-guided method for engineering complex biomimetic materials. Using laser scanning microscopes and twophoton photolithography, they use this method to create patterned poly(ethylene glycol) diacrylate hydrogels that recreate 3D structural and biochemical features of endogenous vascular microenvironments, as shown here for the coronary vasculature. These biomaterials can effectively guide cellular organization in order to recapitulate endogenous vascular structures, marking an important step forward for tissue engineering.

original image
Get access to the full text of this article

Ancillary