• nanotube array;
  • organotypic culture;
  • tissue-substrate interaction;
  • neuronal tissue;
  • adult retina culture;
  • brain slice culture
Thumbnail image of graphical abstract

Organotypic culture of adult neuronal tissue over several weeks is an unresolved challenge due to rapid distortion and cell death. M. Zink, S. G. Mayr, and co-workers demonstrate for the first time on page 2399 that superhydrophilic nanostructured substrates with tunable surface morphologies offer ideal conditions for culturing adult retinal explants (upper right) and adult brain slices (lower left). Even after two weeks, the neuronal tissue structures are maintained without signs of degeneration, which paves the way for in-vitro retina and brain tissue regeneration.