Advanced Materials

Tissue Engineering: Tailoring Substrates for Long-Term Organotypic Culture of Adult Neuronal Tissue (Adv. Mater. 18/2012)

Authors

  • Valentina Dallacasagrande,

    1. Paul-Flechsig-Institute for Brain Research, Universität Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    2. Soft Matter Physics Division, Institut für Experimentelle Physik 1, Universität Leipzig, Linnéstr. 5, 04103 Leipzig, Germany
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Mareike Zink,

    Corresponding author
    1. Soft Matter Physics Division, Institut für Experimentelle Physik 1, Universität Leipzig, Linnéstr. 5, 04103 Leipzig, Germany
    Current affiliation:
    1. These authors contributed equally to this work.
    • Soft Matter Physics Division, Institut für Experimentelle Physik 1, Universität Leipzig, Linnéstr. 5, 04103 Leipzig, Germany
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  • Steven Huth,

    1. Leibniz-Institut für Oberflächenmodifizierung e.V., Permoserstr. 15, 04318 Leipzig, Germany
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  • Alexander Jakob,

    1. Leibniz-Institut für Oberflächenmodifizierung e.V., Permoserstr. 15, 04318 Leipzig, Germany
    2. Translationszentrum für regenerative Medizin/Fakultät für Physik und, Geowissenschaften, Universität Leipzig, Leipzig, Germany
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  • Marcus Müller,

    1. Leibniz-Institut für Oberflächenmodifizierung e.V., Permoserstr. 15, 04318 Leipzig, Germany
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  • Andreas Reichenbach,

    1. Paul-Flechsig-Institute for Brain Research, Universität Leipzig, Jahnallee 59, 04109 Leipzig, Germany
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  • Josef A. Käs,

    1. Soft Matter Physics Division, Institut für Experimentelle Physik 1, Universität Leipzig, Linnéstr. 5, 04103 Leipzig, Germany
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  • S. G. Mayr

    Corresponding author
    1. Leibniz-Institut für Oberflächenmodifizierung e.V., Permoserstr. 15, 04318 Leipzig, Germany
    2. Translationszentrum für regenerative Medizin/Fakultät für Physik und, Geowissenschaften, Universität Leipzig, Leipzig, Germany
    • Leibniz-Institut für Oberflächenmodifizierung e.V., Permoserstr. 15, 04318 Leipzig, Germany.
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Abstract

Organotypic culture of adult neuronal tissue over several weeks is an unresolved challenge due to rapid distortion and cell death. M. Zink, S. G. Mayr, and co-workers demonstrate for the first time on page 2399 that superhydrophilic nanostructured substrates with tunable surface morphologies offer ideal conditions for culturing adult retinal explants (upper right) and adult brain slices (lower left). Even after two weeks, the neuronal tissue structures are maintained without signs of degeneration, which paves the way for in-vitro retina and brain tissue regeneration.

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