DNA Hybridization: Direct Attachment of Microbial Organisms to Material Surfaces Through Sequence-Specific DNA Hybridization (Adv. Mater. 18/2012)

Authors

  • Amy A. Twite,

    1. Department of Chemistry, University of California, Berkeley, and Lawrence Berkeley National Laboratory, Materials Sciences Division, Berkeley, CA 94720-1460, USA
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  • Sonny C. Hsiao,

    1. Department of Chemistry, University of California, Berkeley, and Lawrence Berkeley National Laboratory, Materials Sciences Division, Berkeley, CA 94720-1460, USA
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  • Hiroaki Onoe,

    1. Department of Chemistry, University of California, Berkeley, and Lawrence Berkeley National Laboratory, Materials Sciences Division, Berkeley, CA 94720-1460, USA
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  • Richard A. Mathies,

    1. Department of Chemistry, University of California, Berkeley, and Lawrence Berkeley National Laboratory, Materials Sciences Division, Berkeley, CA 94720-1460, USA
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  • Matthew B. Francis

    Corresponding author
    1. Department of Chemistry, University of California, Berkeley, and Lawrence Berkeley National Laboratory, Materials Sciences Division, Berkeley, CA 94720-1460, USA
    • Department of Chemistry, University of California, Berkeley, and Lawrence Berkeley National Laboratory, Materials Sciences Division, Berkeley, CA 94720-1460, USA.
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Abstract

original image

M. B. Francis and co-workers develop a new chemical method for the attachment of single-stranded DNA molecules to the surfaces of these organisms. On page 2380, they describe how, when exposed to substrates bearing the sequence complements, the microbes can be attached to specified locations with very high efficiency. The use of multiple DNA sequences allows complex microbial ‘communities’ to be generated, potentially allowing the study of symbiotic relationships. Shown are Synechocystis (red), Saccharomyces cerevisiae (green), and Azotobacter vinelandii (blue).

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