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Drug Delivery: Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles (Adv. Mater. 21/2012)

  1. Xinjian Yang,
  2. Xia Liu,
  3. Zhen Liu,
  4. Fang Pu,
  5. Jinsong Ren*,
  6. Xiaogang Qu*

Article first published online: 30 MAY 2012

DOI: 10.1002/adma.201290123

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 21, page 2798, June 5, 2012

Additional Information

How to Cite

Yang, X., Liu, X., Liu, Z., Pu, F., Ren, J. and Qu, X. (2012), Drug Delivery: Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles (Adv. Mater. 21/2012). Adv. Mater., 24: 2798. doi: 10.1002/adma.201290123

Author Information

  1. Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625

*Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.

Publication History

  1. Issue published online: 30 MAY 2012
  2. Article first published online: 30 MAY 2012

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Keywords:

  • mesoporous silica;
  • gold nanorods;
  • drug delivery;
  • photothermal therapy;
  • aptamers
Thumbnail image of graphical abstract

Multifunctional drug-delivery systems have shown promising applications in cancer therapy. J. Ren, X. Qu, and co-workers report a novel, cell-targeting, NIR light responsive drug-delivery system on page 2890, which is based on gold nanorods incorporated within a mesoporous silica framework and surface-functionalized with aptamer DNA. With its high NIR absorbance, good biocompatibility, and selectivity, the as-prepared nanovehicle can be used as chemo-photothermal therapy agent to destroy cancer cells efficiently with high spatial/temperal resolution.

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