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Covalent Cross-Linking: Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross-Linking and Their Application for Specific Cellular Imaging (Adv. Mater. 26/2012)

  1. Jiangbo Yu1,
  2. Changfeng Wu2,
  3. Xuanjun Zhang1,
  4. Fangmao Ye1,
  5. Maria Elena Gallina1,
  6. Yu Rong1,
  7. I-Che Wu1,
  8. Wei Sun1,
  9. Yang-Hsiang Chan1,
  10. Daniel T. Chiu1,*

Article first published online: 3 JUL 2012

DOI: 10.1002/adma.201290160

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 26, page 3577, July 10, 2012

Additional Information

How to Cite

Yu, J., Wu, C., Zhang, X., Ye, F., Gallina, M. E., Rong, Y., Wu, I.-C., Sun, W., Chan, Y.-H. and Chiu, D. T. (2012), Covalent Cross-Linking: Stable Functionalization of Small Semiconducting Polymer Dots via Covalent Cross-Linking and Their Application for Specific Cellular Imaging (Adv. Mater. 26/2012). Adv. Mater., 24: 3577. doi: 10.1002/adma.201290160

Author Information

  1. 1

    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA

  2. 2

    State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China

*Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.

Publication History

  1. Issue published online: 3 JUL 2012
  2. Article first published online: 3 JUL 2012

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Keywords:

  • semiconductors;
  • polymer dots;
  • cross-linking;
  • stable functionlization;
  • cellular imaging
Thumbnail image of graphical abstract

Stable and highly fluorescent small semiconducting polymer dots (Pdots) are prepared by D. T. Chiu and co-workers using a covalent cross-linking strategy described on page 3498. In this confocal fluorescence microscopy image, microtubules in HeLa cells are specifically labeled by the cross-linked Pdots, and individual tubular structures can be seen under 488 nm laser illumination. Cross-linked Pdots are shown to have desirable characteristics for improved labeling efficiency and sensitivity in cellular assays.

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