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Keywords:

  • biodegradable multifunctional polyurethane;
  • smart nanodevices;
  • stimuli-responsive;
  • targeted drug delivery;
  • antitumor
Thumbnail image of graphical abstract

A molecularly engineered super-nanodevice integrates various desired properties in a smart and co-ordinated way, allowing certain functionalities to be switched on or off as required. As shown on page 3639 by H. Tan, Q. Fu, and co-workers, this nanovehicle could break through complex physiological barriers, and then precisely ferry potent toxic drugs into tumor cells in vivo, thus significantly maximizing the therapeutic efficacy and reducing drug toxicity.