Advanced Materials

Functional Nanovehicles: Molecular Engineered Super-Nanodevices: Smart and Safe Delivery of Potent Drugs into Tumors (Adv. Mater. 27/2012)

Authors

  • Mingming Ding,

    1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
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  • Jiehua Li,

    1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
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  • Xueling He,

    1. Laboratory Animal Center of Sichuan University, Chengdu 610041, China
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  • Nijia Song,

    1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
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  • Hong Tan,

    Corresponding author
    1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
    • College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
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  • Yi Zhang,

    1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
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  • Lijuan Zhou,

    1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
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  • Qun Gu,

    1. Ningbo Key Laboratory of Polymer Materials, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
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  • Hua Deng,

    1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
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  • Qiang Fu

    Corresponding author
    1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
    • College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
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Abstract

A molecularly engineered super-nanodevice integrates various desired properties in a smart and co-ordinated way, allowing certain functionalities to be switched on or off as required. As shown on page 3639 by H. Tan, Q. Fu, and co-workers, this nanovehicle could break through complex physiological barriers, and then precisely ferry potent toxic drugs into tumor cells in vivo, thus significantly maximizing the therapeutic efficacy and reducing drug toxicity.

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