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Drug Delivery: Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery (Adv. Mater. 27/2012)

  1. Ran Mo1,
  2. Qiong Sun1,
  3. Jingwei Xue1,
  4. Nan Li1,
  5. Wenyuan Li2,
  6. Can Zhang1,*,
  7. Qineng Ping1

Article first published online: 10 JUL 2012

DOI: 10.1002/adma.201290167

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 27, page 3705, July 17, 2012

Additional Information

How to Cite

Mo, R., Sun, Q., Xue, J., Li, N., Li, W., Zhang, C. and Ping, Q. (2012), Drug Delivery: Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery (Adv. Mater. 27/2012). Adv. Mater., 24: 3705. doi: 10.1002/adma.201290167

Author Information

  1. 1

    Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China

  2. 2

    Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia

*Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

Publication History

  1. Issue published online: 10 JUL 2012
  2. Article first published online: 10 JUL 2012

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Keywords:

  • zwitterions;
  • pH response;
  • drug delivery;
  • cancer therapy;
  • liposomes
Thumbnail image of graphical abstract

Liposomes with multistage pH-response to a mildly acidic tumor extracellular matrix and acidic intracellular compartments are like rockets for transporting anticancer drugs to mitochondria, as reported by C. Zhang and co-workers. On page 3659, liposomes reverse the charge of the tumor microenvironment, enhancing cellular uptake (white flying rocket), escape from endolysosomes (blue sphere), and delivery to mitochondria in tumor cells (black flying rocket), providing a safe, efficient carrier platform for cascade drug delivery on the basis of a kinetic process.

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